If (ALL) synthetic vitamins are the same as natural, how would you explain these known facts?
*Explanation from a reference: "Foods may contain TPP, TTP, thiamin monophosphate (TMP), thiamin, thiamin sulfide, thiamin disulfide, thiamin tetrahydrofurfuryl disulfide (sometimes added to wine), thiamin hydrochloride; thiamin is a monovalent cation at physiological pH. The median intake of adult men in the United States is about 1.9 mg/day" Thus, synthetic thiamine HCL (hydrochloric acid) is also found in a few foods, plus, HCL is naturally secreted into the stomach by the body to maintain an acid medium.
SIDEBAR: Vitamin B12 needs a little more clarification. All forms are for the most part mostly natural since they come from natural sources like bacteria and algae or animals. Scientists have yet to be able to completely create totally synthetic vitamin B12. But, the natural vitamin B12 base is manipulated by adding a mineral (often cyanide) at a certain spot through an enzymatic action, similar to how the body can convert the different forms. What is true is that some forms like the typical one used in many supplements, cyanocobalamin, are not found naturally, so many call it synthetic. It should be called semi-synthetic. The body has to convert cyanocobalamin into the preferred natural forms as methylcobalamin, the most commonly used form, and the less used adsenosylcobalamin. ref These are the physiological body forms. There is still the question as to the best form since the body can convert them all. To what degree this conversion occurs may be the real issue. What happens to the cyanide part after separation is considered a non-issue, but....
We could split hairs talking about slight absorption differences for B and C vitamins, but the end result is to measure the form that the body ultimately utilizes for vitamins and compare how synthetic and natural vitamins differ in generating these forms. Very simple and easy to measure. This would give the net effect for both forms side by side. There are some minor structural differences that may show up in major ways yet to be discovered, similar to the one already known for synthetic folic acid converting in the body into the natural folate form at limited amounts. But up to now, scientific research shows minor differences are mainly in absorption rates and time to reach peak plasma level. Lab C reached peak before food source C. This may also be a factor of quicker elimination, which could be a factor of accessory nutrient(s) presence.
FYI: The body prefers L-ascorbic acid over D-ascorbic acid. Fortunately, D-ascorbate is only used as a preservative in some food products, not as a vitamin C supplement.
What is known is that the functions attributed to vitamins are often the result of enzyme complexes of which the vitamin becomes a part, or from the other nutrients also found with vitamins in foods. The next reference describes the functions of flavonoids in citrus juice. Notice how many are similar to vitamin C functions. In fact, flavonoids probably protect vitamin C and aid it's functions. ref ref
FALSE Concepts: Articles like this one say natural and synthetic vitamins are the same structure (not always true) and they just need other nutrients to complete the vitamin function. Sometimes these other elements are simply combining acids and other times they are other co-enzyme parts, such as vitamins, minerals, and/or protein enzymes. They do not have to be supplied with the vitamin since the body has stores of these available from other food sources and also available from storage areas in the body. Foods seldom contain all the elements necessary to build enzymes. The whole food vitamin companies like to call these other elements co-factors. They say the vitamin needs these co-factors to function. The truth is that vitamins can be both coenzymes and co-factors, not the other way around. Co-enzymes form with enzymes to complete their function while co-factors mainly speed up the action of enzymes. Minerals are often co-factors. Many functions of vitamins are really the action of enzymes. Yes, there are vitamin functions not related to enzymes, as well.
FOODFORM or whole food vitamins on natural vs synthetic
Food form vitamins need to be mentioned here as they love to talk about these issues. Studies show the food form vitamins exhibit greater absorption and blood levels over regular synthetic vitamins. But, when you know that these vitamins start out by feeding some synthetic vitamins to yeast to get them bio-transformed into a food matrix like form, the discussion takes a different turn. The comparison is between synthetic vitamins in a food like matrix versus isolated synthetic vitamins. And yes, having some food elements present often does increase percentage of absorption. This still leaves out the comparisons with true nature created vitamins versus synthetic vitamins unanswered.
One true whole food vitamin supplement is (hyjacked website, return soon). In the others, synthetics are added to yeast or other foods in the production like those for New Chapter, MegaFood, Garden of Life*, and even Standard Process.
*Garden of Life has a new line called the MyKIND ORGANICS that claims to supply all natural vitamins only from food. After reading the patent for this new process and analyzing the nutrient content of the foods selected, while there is a possibility the vitamins are all from food, the reality presents a very high improbability factor. You can read about them here> article
**A study in animals measured blood levels of All-trans or 9-cis beta carotene after each was given separately. After just 9-cis, both all-trans and 9-cis were measured at 50-50 increase. But, after only all-trans, 9-cis only increased about 10% and the rest of the increase was all-trans. The body favors all-trans.